Drug eruption - Sprèadhadh Dhrogaichean
☆ Ann an toraidhean 2022 Stiftung Warentest às a’ Ghearmailt, cha robh sàsachd luchd-cleachdaidh le ModelDerm ach beagan nas ìsle na le co-chomhairlean telemedicine pàighte.
Sprèadhadh Dhrogaichean (Drug eruption) air a chomharrachadh le bhith a 'toirt buaidh air a' bhodhaig gu lèir.
References
Uaireannan faodaidh ath-bhualaidhean craicinn adhbhrachadh le cungaidh-leigheis, ris an canar sprèadhadh dhrogaichean, a bhith dona. Thathas den bheachd gu bheil na droch ath-bhualaidhean sin, ris an canar severe cutaneous adverse drug reactions (SCARs) , a’ bagairt beatha. Nam measg tha suidheachaidhean mar Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Ged a tha SCARs tearc, bidh timcheall air 2% de dh’ euslaintich san ospadal a’ faighinn eòlas orra.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Thadhail boireannach 31-bliadhna air an roinn dermatology le bad dearg gun phian air mullach a cas dheas. Ghabh i aon dòs de doxycycline (100 mg) an latha roimhe, às deidh làimhseachadh laser picosecond airson sgarfaichean acne. An-uiridh, fhuair i cùis coltach ris san aon àite às deidh dhi an aon dòs de làimhseachadh laser doxycycline a ghabhail. Chan eil eachdraidh mheidigeach cudromach aice agus chan eil comharran sam bith eile aice, leithid fiabhras, gu h-ionadail no air feadh a bodhaig.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Tha Stevens-Johnson syndrome (SJS) agus toxic epidermal necrolysis (TEN) nan dà sheòrsa de dhroch ath-bhualadh craiceann, eadar-dhealaichte bho shuidheachaidhean craiceann eile leithid erythema multiforme major agus syndrome craiceann sgaldaichte staphylococcal, a bharrachd air ath-bheachdan dhrogaichean. Is e ath-bhualadh tearc is dona a th’ ann an SJS/TEN a dh’ adhbhraicheas milleadh farsaing air craiceann is membran mucous, gu tric le comharran siostamach. Ann an còrr air 80% de chùisean, is e cungaidhean-leigheis an adhbhar.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Tha sprèadhadh dhrogaichean air a dhearbhadh sa mhòr-chuid bho eachdraidh mheidigeach agus sgrùdadh clionaigeach. Faodaidh biopsy craiceann, deuchainnean fala no deuchainnean imdhun-eòlais a bhith feumail cuideachd.
Is e eisimpleirean de dhrogaichean cumanta a tha ag adhbhrachadh an sprèadhadh antibiotics agus drogaichean antimicrobial eile, drogaichean sulfa, drogaichean neo-steroidal anti-inflammatory (NSAIDs), riochdairean chemotherapy airson malignancies, anticonvulsants agus drogaichean psychotropic.
○ Diagnosis agus Làimhseachadh
Ma tha fiabhras ort (àrdachadh ann an teòthachd bodhaig), bu chòir dhut aire mheidigeach a shireadh cho luath ‘s a ghabhas. Bu chòir an droga a tha fo amharas a stad (me antibiotics, drogaichean neo-steroidal anti-inflammatory). Mus tèid thu dhan ospadal, faodaidh antihistamines beòil leithid cetirizine no loratadine cuideachadh le itching agus broth.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Deuchainn fala (CBC, LFT, cunntadh eosinophil)
Steroids beòil agus antihistamines le òrdugh dotair